Meta-analysis on the Efficacy and Safety of Amisulpride and Risperidone in the Treatment of Schizophrenia
- VernacularTitle:氨磺必利与利培酮治疗精神分裂症疗效和安全性的Meta分析
- Author:
Zhiqiang CHEN
;
Feng ZHOU
;
Huiping CHEN
- Publication Type:Journal Article
- Keywords:
Amisulpride;
Risperidone;
Schizophrenia;
Meta-analysis
- From:
China Pharmacist
2015;(2):280-283
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy and safety of amisulpride and risperidone in the treatment of schizophrenia. Meth-ods:The RCTs literatures on amisulpride and risperidone in the treatment of schizophrenia were retrieved and screened, and the quali-fied ones were analyzed by meta-analysis. Results:A total of 10 literatures were included involving 802 patients. Meta-analysis results showed that the difference between the two groups after the treatment was not statistically significant by comparing the clinical efficien-cy, PANSS score and TESS score. About the incidence of adverse reactions, amisulpride was better than risperidone in the endocrine function, extrapyramidal symptoms, weight gain and cardiovascular system. The incidence of nausea and vomiting of amisulpride was more than that of risperidone. There was no statistical significance in insomnia, headache, dizziness and the others. Conclusion:Ex-isting literature analysis shows that amisulpride is safe and effective in the treatment of schizophrenia.
