Optimization of Preparation Technology of Compound Sodium Lactate Injections for Improvement of Clar-ity
- VernacularTitle:提高复方乳酸钠注射液澄明度的工艺优化
- Author:
Yingying LEI
;
Xiaoqin MA
;
Zhilin HU
- Publication Type:Journal Article
- Keywords:
Orthogonal test;
Compound sodium lactate injections;
Clarity
- From:
China Pharmacist
2015;(2):348-349
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To optimize the preparation technology of compound sodium lactate injections for the improvement of clari-ty. Methods:The orthogonal test was adopted to screen the best preparation conditions using four influencing factors including the de-carburization temperature of the concentrated solution (A), pH value of the concentrated solution (B), decarburization time of the concentrated solution ( C) and the filling temperature of the injections ( D) with 3 levels for each, and the clarity of the injections as the index. Results:The best preparation conditions were as follows:the decarburization temperature was 60℃, pH value of the con-centrated solution was 6. 5, the decarburization time was 20minute and the filling temperature was 50℃. Conclusion: The optimal process can improve the clarity of compound sodium lactate injections.
