Epigenetic modification and the regulatory mechanism of moxibustion in inflammatory bowel disease
10.3969/j.issn.2095-4344.2015.02.025
- VernacularTitle:从表观遗传修饰角度探讨艾灸对炎症性肠病的调控机制
- Author:
Yan HUANG
;
Chuanzi DOU
;
Renjia HUANG
;
Luyi WU
;
Shuoshuo WANG
;
Zhijun WENG
;
Hui FENG
;
Chunhui BAO
;
Huirong LIU
;
Huangan WU
- Publication Type:Journal Article
- Keywords:
Epigenomics;
Organisms,Geneticaly Modified;
Gastroenterology;
Moxibustion
- From:
Chinese Journal of Tissue Engineering Research
2015;(2):294-299
- CountryChina
- Language:Chinese
-
Abstract:
METHODS:A computer-based online research of PubMed, CNKI and VIP databases was performed with the key words of “epigenetic; inflammatory bowel disease; Crohn’s disease; ulcerative colitis; DNA methylation; histone modification; miRNA; moxibustion” in Chinese and English. RESULTS AND CONCLUSION:The correlation of epigenetic modification with inflammatory bowel disease occurrence and development is elaborated. The mechanisms in inflammatory bowel disease have been related from DNA methylation, histone modifications and miRNA targets. The mechanism of moxibustion on inflammatory bowel disease is primarily associated with immune regulation, and its anti-inflammatory mechanism may be affected by epigenetic regulation of inflammatory cytokines.
