Clinical efficacy of central pancreatectomy and distal pancreatectomy：a Meta-analysis of the reserved endocrine and exocrine functions of the pancreas
10.3969/j.issn.2095-4344.2015.02.030
- VernacularTitle:胰腺中段与胰腺体尾切除:保留胰腺内外分泌功能的Meta分析
- Author:
Xinghua CAO
;
Tieying HE
;
Hai LIN
;
Wei HAN
;
Qilong CHEN
- Publication Type:Journal Article
- Keywords:
Pancreas;
Pancreatectomy;
Exocrine Pancreatic Insufficiency;
Pancreatic Fistula
- From:
Chinese Journal of Tissue Engineering Research
2015;(2):322-328
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Central pancreatectomy is a surgical treatment for tumors at the neck or the middle part of the pancreas, which can reserve more normal pancreas, not cut adjacent organs, and reduce the incidence of postoperative internal and external pancreatic secretion deficiency with respect to the expanded proximal and distal pancreatectomy. OBJECTIVE: To systematicaly evaluate the clinical efficacy of the central pancreatectomy and distal pancreatectomy. METHODS: A computer-based search of Chinese and English databases was performed, and then 15 controled clinical trials were included and systematicaly evaluated using RevMa5.2 software. RESULTS AND CONCLUSION: Totaly 1 079 cases were included in this study, which consisted of 436 central pancreatectomy cases and 643 distal pancreatectomy cases. Meta-analysis showed that compared with the distal pancreatectomy group, the incidences of postoperative pancreatic fistula and complications were significantly higher, the risk of postoperative endocrine and exocrine insufficiency were significantly lower, while the surgical time (SMD: 59.23, 95%CI: 22.41-96.05, P < 0.01) and hospital stays (SMD: 7.01, 95%CI: 1.94-12.09,P< 0.01) were longer in the central pancreatectomy group. These findings indicate that although the central pancreatectomy has a high postoperative complication incidence, it can be accepted clinicaly, which may be a reasonable operation method to preserve pancreatic exocrine and endocrine function.
