Associations between polymorphisms of Vitamin D receptor gene and type 1 diabetes susceptibility：A meta-analysis
10.3969/j.issn.1006-6187.2015.02.004
- VernacularTitle:维生素D受体基因多态性与1型糖尿病易感性的Meta分析
- Author:
Guofeng WANG
;
Kuanfeng XU
;
Tao YANG
- Publication Type:Journal Article
- Keywords:
Vitamin D receptor (VDR);
Genetic polymorphism;
Diabetes mellitus,type 1;
Meta-a-nalysis
- From:
Chinese Journal of Diabetes
2015;(2):110-114
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the associations between polymorphisms of Vitamin D receptor gene and type 1 diabetes susceptibility. Methods Literatures were retrieved from PubMed ,Web of Science and WanFang databases ,etc.Pooled odds ratios(ORs) with 95% confidence intervals (CIs) were calculated using a random effect model. Results A total of 28 literatures were included. The result of analysis showed that BsmI and ApaI polymorphism were the susceptibility gene for T 1DM in Asian populations [B vs b;OR(95% CI)=1.53(1.06~2.20) ,P=0.024 ;AA vs aa:OR(95% CI)=1.60(1.06~2.40) ,P= 0.023]. Conclusion The BsmI and ApaI polymorphism may be susceptibility gene in Asians populations with T1DM.
