Study on the correlation between the seven single nucleotide polymorphisms and genesis of type 2 diabetes mellitus

VernacularTitle:7个单核苷酸位点多态性与2型糖尿病风险因素的相关性研究
Author: Xingju LUO ; Changming CHENG ; Yan XIE
Publication Type:Journal Article
Keywords: Single nucleotidepolymorphisms (SNPs ); Diabetes mellitus,type 2; High-resolution melting (HRM ) curve
From:Chinese Journal of Diabetes 2015;(2):115-118
CountryChina
Language:Chinese
Abstract: Objective To investigate onthe correlation between the seven single nucleotide polymorphisms and genesis of T2DM. Methods High‐resolution melting (HRM ) curve technology was used to detect thegenotype of the seven SNPs in 202 T2DM patients and 200 healthy volunteers. The relationship between susceptible gene polymorphism and T 2DM was analyzed. Results The frequency of five SNP loci rs8050136 ,rs13266634 ,rs7578597 ,rs864745 and rs7961581 showed significant differences between T2DM patients and controls ( P< 0.01 ). The OR of rs8050136 ,rs13266634 ,rs757859 and rs864745 was >1 ,while OR of rs7961581 was <1. There was no significant difference in rs10811661 and rs10923931 loci between T2DM patients and controls (OR=1). Conclusion The polymorphism of loci rs8050136 ,rs13266634 ,rs7578597 and rs864745 is associated with T2DM genesis in this study population , while rs10811661 and rs10923931 is not associated with T 2DM genesis ,and rs7961581 may be a protective factor for T2DM.