Research progress on the role of transcription factor Nrf 2 in diabetic nephropathy
10.3969/j.issn.1006-6187.2015.02.020
- VernacularTitle:转录因子NEF2相关因子2在糖尿病肾病中的研究进展
- Author:
Pan GAO
;
Nong ZHANG
- Publication Type:Journal Article
- Keywords:
NE-F2-related factor 2(Nrf2);
Diabetic nephropathy (DN);
Reactive oxygen species (ROS);
Activators
- From:
Chinese Journal of Diabetes
2015;(2):182-184
- CountryChina
- Language:Chinese
-
Abstract:
Oxidative stress and inflammation are two main factors in the progress of diabetic nephropathy(DN) and its complications. NF‐E2 p45‐related factor (Nrf2) is a crucial transcriptional factor which manipulates downstream genes that encode some antioxidant enzymes and phase Ⅱ detoxifying enzymes ,to maintain the redox homeostasis and cellular detoxification response. Therefore ,more and more researchers are focusing on the role of Nrf2 in DN. In this review ,the detailed role of Nrf2 in DN will be discussed. Hopefully ,our work can epitomize recent research progress and provide novel clues for diabetic nephropathy prevention and treatment.
