Expression of apolipoprotein A-Ⅰin eight histological types of renal neoplasms
10.3969/j.issn.1671-167X.2015.01.029
- VernacularTitle:载脂蛋白 A-Ⅰ在8种不同组织学分型肾肿瘤中的表达
- Author:
Bei GONG
;
Huihui HU
;
Man ZHANG
- Publication Type:Journal Article
- Keywords:
Apolipoprotein A-Ⅰ;
Kidney neoplasms;
Immunohistochemistry;
Biological markers
- From:
Journal of Peking University(Health Sciences)
2015;(1):155-159
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of apolipoprotein A-Ⅰ( ApoA-Ⅰ) in eight histo-logical types of renal neoplasms and to explore a new biomarker for differential diagnosis .Methods:The immunochemistry was used to detect the expression of ApoA-Ⅰ in 23 cases of renal tumors , including clear cell carcinoma , papillary cell carcinoma , chromophobe cell carcinoma , oncocytoma , multilocular cystic carcinoma , renal pelvis invasive urothelial carcinoma , metanephric adenoma and collecting ducts carcinoma.Five cases of cancer-adjacent normal tissues were obtained from another five renal tumor pa-tients and were chosen as control group .Results: In the 23 cases of renal tumors , ApoA-Ⅰ was ex-pressed in 21 cases(positive rate was 91.3%).There were only two in five cases of normal tissues which expressed this protein ( positive rate was 40 .0%) .A significant differentiation was observed between the two groups(Z=-2.829,P=0.003).In renal clear cell carcinoma(RCC), ApoA-Ⅰ expression level was correlated with the grade and stage of tumor tissues .ApoA-Ⅰ was stained much more stronger in RCCⅡ-Ⅲ than in RCCⅠ( Z=-2.070,P=0.038).In various histological types of renal cancer , ApoA-Ⅰwas all expressed to some degrees .Conclusion:ApoA-Ⅰcan be chosen as a tumor biomarker to differentiate various histological types of renal neoplasms .
