Evaluation the effect of pantoprazole, amoxicillin and clarithromycin (PAC500) in the treatment of gastric and duodenal ulcer patients with H.pylori infection
- Author:
Tran Ngoc Bao
- Publication Type:Journal Article
- Keywords:
gastric - duodenal ulcer, combined treatment
- MeSH:
Therapeutics;
Helicobacter pylori;
Duodenal Ulcer;
Stomach Ulcer;
Pharmaceutical Preparations;
2-Pyridinylmethylsulfinylbenzimidazoles;
Amoxicillin;
Clarithromycin
- From:Journal Ho Chi Minh Medical
2004;8(4):204-209
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Therapeutics; Helicobacter pylori; Duodenal Ulcer; Stomach Ulcer; Pharmaceutical Preparations; 2-Pyridinylmethylsulfinylbenzimidazoles; Amoxicillin; Clarithromycin
Study on the effect of PAC500 regimen in the treatment of peptic ulcer disease with H. pylori (+) in 33 patients. The results showed that, this regimen is good with the mean value of pain relief is 6.5 days in addition to the high percentage of ulcer healing (96.9%: protocol and 93.9%: intention of treatment) and the high percentage of H.pylori eradication (87.5%: protocol and 84.8%: intention of treatment). Beside, there is an improvement of the acute gastritis lesion on gastric mucosa after the eradication. But the high percentage of side-effects (81.8%) must be considered, bitter sensation of the mouth is the most common and can be tolerated. Reported only 1 case had to withdraw this trial because of vomitting side-effect
