The relationship of plasma homocysteine and the polymorphism of MTHFR gene with brain infarction in type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2015.02.003
- VernacularTitle:血清同型半胱氨酸及亚甲基四氢叶酸还原酶基因多态性与2型糖尿病合并脑梗死的相关性研究
- Author:
Xiaodi ZHAO
;
Li WANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Brain infarction;
Homocysteine methy lenetetrahy drofolate reductase (NADPH2)
- From:
Chinese Journal of Diabetes
2015;(2):107-109
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of plasma homocysteine and the polymorphism of MTHFR gene with ischemic stroke in type 2 diabetes. Methods Serum Hcy ,folic acid and the polymorphism of MTHFR gene were compared among 81 T2DM patients with brain infarction (T2DM+BI) and 325 T2DM patients without brain infarction (T2DM ). Results All the genotypes of T2DM group and T2DM+BI group followed the hardy‐weinberg law. There was no significant difference in the frequency of mutant alleles (T) in site 677 of MTHFR gene and in frequency of TT genotype between the groups of T2DM and T2DM + BI (64.15% vs 60.15% and 42.5% vs 34.5% ,P > 0.05 ). The concentration of Hcy was significantly higher in patients with TT genotype than with CC genotype (14.4 ± 7.86) vs (10.58 ± 3.37)mmol/L(P<0.01). Conclusion There is no correlation between polymorphism of MTHFR gene and stroke in T2DM patients. The mutation of MTHFR C677T is associated with hyperhomocysteinemia.
