The Early Diagnostic Value of Thyroid Hormone Level in Patients With Left Ventricular Diastolic Dysfunction
10.3969/j.issn.1000-3614.2015.02.012
- VernacularTitle:甲状腺激素水平对左心室舒张功能障碍患者的早期诊断价值
- Author:
Song GAO
;
Jie YAN
;
Feng ZHANG
;
Dingye WU
;
Yu ZHANG
- Publication Type:Journal Article
- Keywords:
Thyroid hormone;
Diastolic function;
Doppler tissue imaging;
NT-proBNP;
rT3
- From:
Chinese Circulation Journal
2015;(2):140-143
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the early diaghostic value of thyroid hormone level in patients with left ventricular diastolic dysfunction. Methods: Our work included 4 groups:①Normal control group, n=40,②Impaired left ventricular diastolic function
group, n=40,③Failure of left ventricular diastolic function group, n=41 and④Impaired left ventricular systolic function group, n=40. The cardiac function was assessed by color Doppler lfow imaging and tissue Doppler imaging for the early diastolic mitral lfow velocity (E), the peak early diastolic mitral annular velocity (Em) and the ratio of E/Em. The blood levels of NT-proBNP and FT3, FT4, TSH, rT3 were examined in clinical laboratory.
Results: Blood levels of FT3 and rT3 were different in pair wise comparison among 4 groups, P<0.05, and FT4 and NT-proBNP were different in pair wise comparison among 4 groups, except for Normal control group and Impaired left ventricular diastolic function group, P<0.05. The TSH level was similar among 4 groups, P>0.05. The ratio of E/Em was negatively related to FT3 (r=-0.724, P<0.05) and FT4 (r=-0.49, P<0.05), while positively related to rT3 (r=0.87, P<0.05) and NT-proBNP (r=0.83, P<0.05).
Conclusion: The changes of thyroid hormone level may exist in patients with impaired diastolic function and it may vary with the severity of the cardiac dysfunction. Blood levels of NT-proBNP with thyroid hormone might be used as a reference index for early diagnosis of diastolic dysfunction.
