Correlation between pulse pressure and cystatin C level in aged patients with essential hypertension

VernacularTitle:老年原发性高血压患者脉压与胱抑素C的相关性
Author: Xiangdong MENG ; Juan LI
Publication Type:Journal Article
Keywords: Hypertension; Cysteine proteinase inhibitors; Renal insufficiency
From: Chinese Journal of cardiovascular Rehabilitation Medicine 2015;24(1):24-26
CountryChina
Language:Chinese
Abstract: Objective:To measure serum level of cystatin C (Cys C)in patients with essential hypertension (EH)and analyze its correlation with pulse pressure (PP).Methods:A total of 60 EH patients and 30 cases with normal physi-cal examination results were selected.According to PP level,EH patients were divided into PP>60mmHg group (n=29)and PP≤60mmHg group (n=31).Serum Cys C concentration was measured by latex particle-enhanced immu-noturbidimetric method in two groups,and the results were statistically analyzed.Results:Cys C level of PP >60mmHg group was significantly higher than that of PP≤60mmHg group,and the both groups were significantly higher than that of normal control group [(1.40±0.06)mg/L vs.(1.19±0.54)mg/L vs.(0.72±0.20)mg/L], P <0.05 all;linear correlation analysis indicated that Cys C level was positively correlated with PP (r =0.325,P <0.05)and systolic blood pressure (SBP,r = 0.399,P < 0.05),and PP was positively correlated with SBP (r =0.876,P <0.01)in EH group.Conclusion:Cys C level is positively correlated with PP in EH patients.Cys C level can be used as an early index detecting renal function damage caused by hypertension.