A experimental study on the effect of tendon-bone healing after anterior cruciate ligament reconstruction through BFGF and PDGF

VernacularTitle:BFGF、PDGF 对兔膝前交叉韧带重建术后早期腱骨愈合影响的实验研究
Author: Qingjun DU ; Peiqiang SU ; Jiaqiang HE ; Mingguang HUANG
Publication Type:Journal Article
Keywords: fibroblast growth factor 2; platelet derived growth factor; tendonbone healing; ACL
From: Chongqing Medicine 2015;(6):746-748
CountryChina
Language:Chinese
Abstract: Objective To observe the effect of tendon-bone healing after anterior cruciate ligament reconstruction through BFGF and PDGF.Methods Based of seventy two healthy matured New Zealand white rabbits underwent ACL reconstruction.Devide three groups through different methods,group BFGF,group PDGF,group normal.Results The maximum loads of group BFGF and PDGF after 2 and 5 weeks are higher than group normal,there was significant difference in maximum loads (P <0.05).The max stiffness of group BFGF and PDGF after 2 and 5 weeks are higher than group normal,there was significant difference in maximum loads(P <0.05).Conclusion The group BFGF and PDGF can promote tendon-bone healing by increasing the vascularization and blood vessels of the tendon-bone interface and vascular endothelial growth factor.In biomechanics,group BFGF and PDGF can pro-mote maximum loads、max stiffness and hardness of tendon-bone healing.