The minimum local analgesic concentration of epidural bupivacaine with hydromorphone for labour
10.3969/j.issn.1671-8348.2015.06.019
- VernacularTitle:氢吗啡酮对硬膜外阻滞分娩镇痛时布比卡因最低有效浓度的影响
- Author:
Lei LIN
;
Chun CHEN
;
Qibin KE
;
Heqing TANG
;
Wei FANG
;
Jun HOU
- Publication Type:Journal Article
- Keywords:
hydromorphone;
bupivacaine;
parturition;
minimum local analgesic concentration
- From:
Chongqing Medicine
2015;(6):772-774
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the minimum local analgesic concentration(MLAC)of epidural hydromorphone combined with bupivacaine for analgesia during the first stage of labor by establishing clinical model.Methods Sixty four labouring parturi-ents at 3-7 cm cervical dilation who requested epidural analgesia were allocated to one of two groups.After a lumbar epidural cath-eter was placed,study participants received 15 mL bupivacaine(n=30),bupivacaine with hydromorphone 200 μg(n=30).The con-centration of bupivacaine was determined by the response of the previous patient using 0 - 100 mm visual analog pain scores, with≤30 mm within 30 min defined as effective.Results Four women were excluded,leaving 30 patients in each of the two groups for analysis.The MLAC of bupivacaine alone was 0.103%(95% CI :0.094%-0.113%).The addition of hydromorphone at doses of 200 μg resulted in significant reduction(P <0.05)in the MLAC of bupivacaine to 0.044%(95% CI :0.034%-0.053%),the difference was significant (P <0.05).There was no significant difference in Bromage scores,HR,BP,FHR,UC and adverse reac-tion (P >0.05).Conclusion The study showed a significant reduction in the MLAC of bupivacaine by hydromorphone.Hydromor-phone could be safely used in epidural analgesia for labor.
