Meta-analysis of expression and clinical significance of cyclinD1 in oral squamous cell carcinoma
10.3969/j.issn.1671-8348.2015.06.032
- VernacularTitle:CyclinD1在口腔鳞状细胞癌中表达及其意义的 Meta 分析
- Author:
Hong DONG
;
Xiaoyan ZHANG
;
Youlin SHI
- Publication Type:Journal Article
- Keywords:
neoplasms,squamous cell;
cyclinD1;
immunohistochemistry;
Meta analysis
- From:
Chongqing Medicine
2015;(6):807-809
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions and significance of cyclinD1 in oral squamous cell carcinoma (OSCC). Methods The published studies were searched in the Cochrane Library,Embase,PubMed,CNKI,VIP,Wanfang and CBM databas-es,the quality of the included studies was assessed.Revman5.0.1 software was adopted to test for heterogeneity of the selected re-search literature and analyze the correlation of cyclinD1 and OSCC by calculating OR and 95%CI .Results A total of 31 case-con-trol studies were included in the study,the case group (OSCC group)was 1 604 cases and the control group was 864 cases (inclu-ding normal oral mucosa tissue 452 cases and precancerous lesions 412 cases).The Meta analysis of results showed that the expres-sion of CyclinD1 in oral squamous cell carcinoma was significantly higher than normal tissue[OR (95%CI )at 11.92 (6.71 -21.18)].CyclinD1 was related to differentiated degree,lymph node metastasis and clinical stage of OSCC positively(P <0.05),but was not related to age and gender (P >0.05).Conclusion According to the current relevant research,the over expression of cy-clinD1 is closely related to occurrence and development of OSCC,which might be valuable for the early diagnosis,treatment,and prognosis of OSCC.
