Expression of SCGN and CgA in pancreatic neuroendocrine tumors

VernacularTitle:SCGN 和CgA 在胰腺神经内分泌肿瘤的表达
Author: Lei XUE ; Dandan LI ; Wuyan PANG
Publication Type:Journal Article
Keywords: secretagogin; chromogranin A; panereatic neuroendoerine tumours
From: Chongqing Medicine 2015;(5):638-640
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of secretagogin(SCGN) and chromogranin A(CgA) in pancreatic neuroen‐docrine tumors (PNETs) .Methods Totally 54 cases of PNETs hospitalized in our hospital from October 2007 to October 2013 were enrolled in our study .Immunohistochemical detection was used to determine secretagogin and CgA .Results Secretagogin and CgA were highly expressed in all PNETs specimens .Compared with CgA ,secretagogin were highly expressed in the non‐functional PNETs ,tumor volume>30 cm3 ,the enveloped ,vascular invasion and lymph node metastasis (P<0 .05) .There were no statistically significant difference between SCGN and CgA in functional PNETs tumor volume ≤30 cm3 ,no enveloped ,no vascular invasion and lymph node metastasis(P>0 .05) .Conclusion The expression of secretagogin and CgA in tumor combined with PNETs pathologi‐cal characteristics can predict the severity of PNETs .