Technology research on the preparation of fosfomycin trometamol from fosfomycin sodium
10.3969/j.issn.1671-8348.2015.05.036
- VernacularTitle:磷霉素钠制备磷霉素氨丁三醇的工艺研究
- Author:
Chen HUANG
;
Jing YAN
;
Yigang DING
;
Chao WANG
- Publication Type:Journal Article
- Keywords:
fosfomycin trometamol;
inorganic bisalt method;
synthesis;
process
- From:
Chongqing Medicine
2015;(5):678-680
- CountryChina
- Language:Chinese
-
Abstract:
Objective to investigate a new synthesis for the preparation of fosfomycin tromethamine and to seek for the opti‐mized process and crystallization conditions .Methods An inorganic method ,utilizing in situ generated tromethamine bisulfate to re‐act with fosfomycin sodium was used to gain fosfomycin tromethamine .Results After the optimization of reaction and crystalliza‐tion condition ,it can produce fosfomycin tromethamine .Conclusion Inorganic acid salt synthesis technology is feasible with high yield .
