Influence of thrombus aspiration combined tirofiban on patients with acute STEMI after primary PCI
10.3969/j.issn.1008-0074.2015.01.14
- VernacularTitle:血栓抽吸联合替罗非班对急性 STEMI 直接 PCI 术后的影响
- Author:
Changjin DENG
;
Luping JIN
;
Wei CHENG
;
Guozheng WEI
;
Xiaodong XU
;
Ling SHAO
;
Na PENG
- Publication Type:Journal Article
- Keywords:
Thromboembolism;
Myocardial infarction;
Suction;
Tirofiban
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2015;24(1):50-54
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the influence of thrombus aspiration combined tirofiban on patients with acute ST seg-ment elevation myocardial infarction (STEMI)after primary percutaneous coronary intervention (PCI).Methods:A total of 98 patients,who received primary PCI because of STEMI in our hospital from Jan 2012 to Mar 2013,were selected.They were divided into thrombus aspiration group (n=48,received pure thrombus aspiration)and com-bined treatment group (n = 50,received thrombus aspiration combined intracoronary tirofiban injection during PCI).Coronary angiography (CAG)instantly after PCI and follow-up condition during hospitalization and six months after discharge were compared between two groups.Results:(1)Compared with thrombus aspiration group after PCI,there were significant rise in TIMI blood flow grade [(2.3±0.6)grades vs.(2.7±0.3)grades],per-centage of TIMI flow grade 3 (72.9% vs.90.0%)and ST segment regression >50% rate within 90min after PCI (52.1% vs.74.0%),P < 0.05 or < 0.01,and significant reduction in percentage of postoperative no-reflow (18.8% vs.4.0%,P =0.038)in combined treatment group in hospital;(2)After six-month follow-up,left ven-tricular ejection fraction (LVEF)of combined treatment group was significantly higher than that of thrombus aspi-ration group [(58±6.3)% vs.(51±5.6)%,P <0.05].Conclusion:Thrombus aspiration combined tirofiban can effectively reduce coronary thrombus burden and improve cardiac function in STEMI patients during primary PCI.
