Pathological and prognosis analysis of acute kidney injury associated with clindamycin

VernacularTitle:克林霉素致急性肾损伤12例临床分析
Author: Tao LIU ; Gen LI
Publication Type:Journal Article
Keywords: Acute kidney injury; Clindamycin
From: Chinese Journal of Primary Medicine and Pharmacy 2015;(5):723-725
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical and pathological manifestation of acute kidney injury ( AKI) following infusion of clindamycin .Methods 12 patients were diagnosed as the infusion of clindamycin induced AKI .The clinical and pathological manifestations of these patients were investigated .Results 8 patients (66.7%) had episodes of gross hematuria .Oliguria and anuria was in 6 patients(50.0%).The histological diagnosis of acute interstitial nephritides(AIN) included 5 patients(83.3%).The immunofluorescent examination was negative in all cases .Renal replacement therapy were delivered to four patients .Prednisone was prescribed to 7 patients .All of patients discharged from the hospital and free of renal replacement therapy .The level of serum creatinine decreased to normal 6 months later .Conclusion Most of the AKI associated with clindamycin was oliguria with episodes of gross hematuria ,while the manifestations of skin rash were uncommon .The histological changes revealed AIN .The recent prognosis was relatively good ,but the long-term prognosis should be investigated .