The effect of Gegen Qinlian decoction on serum high sensitive C-reactive protein expression in rats with pe-riodontitis and atherosclerosis
10.3969/j.issn.1001-3733.2015.02.07
- VernacularTitle:葛根芩连汤对牙周炎合并动脉粥样硬化大鼠血清超敏C-反应蛋白表达的影响
- Author:
Xin LUO
;
Xiaojie FENG
;
Dan WANG
;
Wei PENG
- Publication Type:Journal Article
- Keywords:
Gegen Qinlian decoction;
Periodontitis;
Atherosclerosis;
High sensitive C-reactive protein(hs-CRP)
- From:
Journal of Practical Stomatology
2015;(2):180-183
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of Gegen Qinlian decoction on serum high sensitive C-reactive protein(hs-CRP)expres-sion of rats with periodontitis and atherosclerosis(P-AS).Methods:40 male Wistar rats were randomly divided into 2 groups:control group(A,n=1 0),P-AS group(B,n=30).5 rats in group A and B were used for the identification of P-AS model.Then rats with P-AS in group B were randomly divided into 5 groups(n=5)and administered with saline(B1 ),atorvastatin(B2),metronidazole (B3),atorvastatin+metronidazole(B4)and Gegen Qinlian decoction(B5)respectively for 4 weeks.Serum hs-CRP level was assayed by ELISA.Periodontal attachment loss(AL)and artery change were examined by pathology.Results:Serum hs-CRP level in group B1-5 was higher than that of group A(P<0.01 ).Serum hs-CRP level of group B4 and B5 was lower than that of group B1-3(P<0.01 ),B4 vs B5,P>0.05.The inflammation of periodontal tissues in group B2-5 was improved more than that in group B1 .AL in group B4 and B5 were lower than that in other groups(P<0.01 ),B4 vs B5,P>0.05.Histopathological observation of arteries re-vealed that there was no foam cell in group B4 and B5 ,the artery wall in group B4 and B5 was more even and muscle fibers were ar-ranged more regular.Conclusion:Gegen Qinlian decoction may decreas serum hs-CRP expression and depress the development of pe-riodontitis and atherosclerosis.
