Expression and the prognosis value of CXCL1 2/CXCR4 in adenoid cystic carcinoma

VernacularTitle:CXCL12／CXCR4在腺样囊性癌中的表达及对预后的价值
Author: Yingbin HUANG ; Xiaolin NONG ; Yiping YANG ; Yang CAO ; Jiaquan LI
Publication Type:Journal Article
Keywords: Adenoid cystic carcinoma; CXCL1 2/CXCR4; Invasion; Metastasis; Clinical prognosis
From: Journal of Practical Stomatology 2015;(2):210-214
CountryChina
Language:Chinese
Abstract: Objective:To investigate the expression of CXCL1 2 and CXCR4 in adenoid cystic carcinoma(ACC)and to explore its re-lationship with clinicopathologic characteristics and prognosis of the patients.Methods:The expression of CXCL1 2 and CXCR4 in af-fected tissue was detected immunohistochemically in 62 cases of ACC.Both of the two factors and clinicalpathology factors were pro-cessed in accordance with the Kaplan-Meier method and the COX regression model.Results:The positive rates of CXCL1 2 and CX-CR4 expression were 54.8%(34/62)and 77.42%(48/62)respectively.Patients with the 2 factor expression had a shorter survival time than those without them(P<0.05).Multivariate analysis revealed that CXCR4 expression,clinical stage,histological differentia-tion and metastasis/recurrence were independent risk factors for the prognosis of ACC patients.Conclusion:The expression of CXCR4 may be correlated with the malignancy of ACC.CXCR4 expression,clinical stage,metastasis/recurrence and histological differentia-tion can indicate the prognosis of ACC patients.