Effect of baicalin on expression of VEGF, BMP-2 and IL-1βin rat mobile dental periodontitis maintained phase
- VernacularTitle:黄芩苷对牙周炎大鼠牙移动保持阶段VEGF、BMP－2及IL－1β表达的影响
- Author:
Ling LI
- Publication Type:Journal Article
- Keywords:
periodontitis;
baicalin;
VEGF;
BMP-2;
IL-1β
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(3):32-35
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe effect of baicalin on VEGF, BMP-2 and IL-1βexpression in rat mobile dental periodontitis maintained phase, and explore the mechanism of baicalin on periodontal tissue remodeling.Methods 80 SD rats were randomly divided into four groups,20 rats in each group.The blank group weren’t giren any treatment, model group were built with periodontitis, control group and observation group were built with periodontitis and then tooth movement model.The observation group were given baicalin, blank group and control group were given the same volume of saline.The rats were killed at 1d, 3d, 6d, 12d, 18d, then samples of the maxilla were taken to make tissue sections and immunohistochemical staining. VEGF, BMP-2 and IL-1βexpression were observed in periodontal tissue.Results The BMP-2 expression isn’t obvious in blank group, but was obvious in model group, and gradually reduced at the end of the afterburner; BMP-2 expression in experimental group were higher than that in control group at the same point ( P<0.05 ) .The VEGF expression in control group and experimental group gradually reduced at the end of the afterburner; VEGF expression in experimental group were lower than that in control group at the same point ( P<0.05 ) .The IL-1βexpression wasn’t obvious in blank group, but was obvious in model group.The IL-1βexpression in control group and experimental group gradually reduced at the end of the afterburner;IL-1βexpression in experimental group were lower than that in control group at the same point ( P<0.05 ) .Conclusion Baicalin can significantly increase the expression of IL-1βin periodontal tissues of periodontitis rats after moving teeth, reduce inflammation, inhibit bone resorption, and also increase BMP-2 and VEGF expression, promote periodontal vessel formation and maturation, which may be one of the mechanisms of baicalin to promote periodontal tissue remodeling in periodontitis rats at holding phase after orthodontic tooth movement.
