The polyamidoamine induced mineral deposition on dentin surface in vitro
10.3969/j.issn.1001-3733.2015.02.013
- VernacularTitle:聚酰胺－胺诱导牙本质表面矿物沉积的体外实验
- Author:
Fangfang XIE
;
Xiaolang WEI
;
Yan LIU
;
Qiurong LI
;
Tong ZHOU
- Publication Type:Journal Article
- Keywords:
Polyamidoamine dendrimer(PAMAM);
Biomimetic synthesis;
Dentin hypersensitivity
- From:
Journal of Practical Stomatology
2015;(2):205-209
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the sealing ability of the 3.0th generation of polyamidoamine dendrimer(3.0 PAMAM)on hu-man dentinal tubules.Methods:1 6 extracted premolars were cut into 2 mm thick dentin slices to establish sensitive dentin model in vitro.Then 2 samples without any treatment were selected randomly into demineralized dentin group,and the remain 1 4 dentine pills were divided into 2 groups by the random number table(n=7).Samples in the experimental group were treated with 3.0 PAMAM, those in the control group were treated with deionized water.After having immersed in the artificial saliva for 2 and 4 weeks respec-tively,the dentin slices were examined by scanning electron microscope(SEM)and X-ray energy dispersive spectroscopy(EDS). Results:SEM showed that the minerals on the surfaces of the dentine disks in experimental group were formed gradually with the time,the dentinal tubules were blocked 4 weeks after treatment.The minerals on the sample surface in control group were less and the dentinal tubules remained open.EDS results showed that Ca/P(1 .49 ±0.1 6)of mineral deposition in the experimental group was higher than that in the control group (1 .1 8 ±0.20)(P<0.05).Conclusion:The 3.0th generation of PAMAMhas the occlu-ding ability by inducing remineralization on the dentine surface and it may be used in the treatment of dentin hypersensitivity.
