Effect of aconitine on serum zinc finger protein 41 and SPARC in ventricular septal defect model rats
- VernacularTitle:乌头碱对室间隔缺损模型大鼠血清锌指蛋白41和富含半胱氨酸的酸性分泌蛋白的影响研究
- Author:
Cheng YU
- Publication Type:Journal Article
- Keywords:
aconitine;
ventricular septal defect;
zinc finger protein 41;
secreted protein acidic and rich in cysteine
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(3):42-44
- CountryChina
- Language:Chinese
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Abstract:
Objective To explore the effect of aconitine on serum zinc finger protein 41 and secreted protein acidic and rich in cysteine in ventricular septal defect model rats.Methods 80 ventricular septal defect model rats were randomly divided into two groups, experimental group ( n=40) were treated with 0.05 mg/kg aconitine via tail vein injection for 7 consecutive days;control group (n=40) were treated with normal saline via tail vein injection for 7 consecutive days.Then, the abdominal aorta blood of each rat was collected, and the contents of zinc finger protein 41 and SPARC in two groups were detected by Western blot and ELISA method,seperately.Results Western blot results showed that the expression of zinc finger protein 41 and SPARC in serum samples of experimental group were significantly lower than that of control group ( P<0.05 ) .ELISA results showed that the contents of zinc finger protein 41 and SPARC of experimental group was significantly lower than that of control group ( P<0.05 ), respectively.Conclusion Aconitine can decrease the expression of serum zinc finger protein 41 and SPARC in ventricular septal defect model rat.
