Effects of traditional Chinese medicine chrysanthemum decoction on Pediatric RSV infection after A549 cell chemotactic factor
- VernacularTitle:中药菊花煎剂对小儿RSV感染A549细胞后趋化因子影响的研究
- Author:
Yueting PAN
;
Liang ZHU
- Publication Type:Journal Article
- Keywords:
chrysanthemum Chinese medicine decoction;
pediatric pneumonia;
respiratory syncytial virus( RSV);
chemokines
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(3):82-84
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study effect of traditional Chinese medicine chrysanthemum decoction on RSV infection after A549 cells chemotactic factor.Methods Subjects from The Second Hospital Affilated To Suzhou University in recent days, 64 cases of patients diagnosed with RSV effected pneumonia by clinical examination, RSV infection A549 cell model was established and the infected cells were cultured, chrysanthemums with TCM decoction and conventional antiviral observed its effect on RSV infection cell survival, compared two groups of cell SAP was determined by ELISA kit and the expression of RANTEs and chemokines MCP-1.Results Chrysanthemum, according to the results of in vitro cell culture studies traditional Chinese medicine decoction had the effect of directly inhibit the growth of virus replication, and there were some positive effects RSV infected A549 cells, MCP-1 and RANTEs expression or release significantly increased ( P<0.05 ) .Chrysanthemum Chinese medicine decoction and antiviral drugs after the intervention, the expression of MCP-1 and RANTES reduced significantly (P<0.05), but overall volume was still significantly higher than the normal. Conclusion Chrysanthemum Chinese medicine decoction can inhibit RSV infected A549 cells release chemokine RANTEs and MCP-1 to some extent, and then reduce the airway inflammation reaction of children.
