Effect of QianlieShutong capsule combined with tamsulosin on serum testosterone and estrogen in patients with benign prostatic hyperplasia and its efficacy
- VernacularTitle:前列舒通胶囊联合坦索罗辛对良性前列腺增生患者血清睾酮、雌二醇水平的影响及其临床疗效研究
- Author:
Hao LI
;
Qinghui MI
;
Yongjun GAO
;
Jie JIN
- Publication Type:Journal Article
- Keywords:
QianlieShutong capsule;
tamsulosin;
benign prostatic hyperplasia;
testosterone;
estrogen
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(3):89-91
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of QianlieShutong capsule in combination with tamsulosin in the treatment of benign prostatic hyperplasia ( BPH) and its effects on serum testosterone and estrogen.Methods 114 cases of BPH were randomly divided into control group (n=54) and observation group (n=60).The control group were treated with tamsulosin, while the observation group were treated with QianlieShutong capsule in combination with tamsulosin.Then, the curative efficacy, improvement of related indexes, level of serum testosterone, estrogen and adverse reactions were compared.Results The observation group had a total therapeutic efficacy ratio of 95.0%, which was statistically higher than that of 83.3% in control group (P<0.05).In comparison with control group after the treatment, international prostate symptom score (IPSS), residual urine (Ru), prostate volume (PV) in observation group statistically decreased, and maximum flow rate (Qmax), level of estrogen increased (all P<0.05), while level of testosterone in two groups was statistically same.During the treatment, there’ s no case of severe adverse reaction.And the incidence of adverse reactions in the observation group was 13.3%, which was statistically same with that of 11.1% in control group.Conclusion Combined treatment of QianlieShutong capsule and tamsulosin is effective for BPH, which can significantly increase curative efficacy, improve related indexes and regulate level of sexual hormone with minor adverse reactions.
