HIF-1αprotein expression in oral submucous fibrosis tissue
10.3969/j.issn.1001-3733.2015.02.018
- VernacularTitle:口腔黏膜下纤维化组织中缺氧诱导因子-1α的表达
- Author:
Lin LIN
;
Tianyou LING
- Publication Type:Journal Article
- Keywords:
Oral submucous fibrosis;
Hypoxia inducible factor-1α;
Immunohistochemistry
- From:
Journal of Practical Stomatology
2015;(2):230-232
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effects of HIF-1αprotein in the pathogenesis of oral submucous fibrosis(OSF)tissue.Meth-ods:HIF-1αprotein expression in 30 cases of OSF,5 cases of normale control oral mucosa tissue was studied by SP immunohisto-chemistry with HIF-1αrabbit anti-human polyclonal antibody.Results:The negative expression of HIF-1αwas found in normal oral mucoa tissue and possitive in early,intermediate and advanced stage of OSF(P<0.05 ).Conclusion:HIF-1αprotein may play an importent role in the pathogenesis of OSF.
