The role of 11β-HSD1 in metabolic syndrome
10.3969/j.issn.1006-6187.2015.04.025
- VernacularTitle:11β-羟基类固醇脱氢酶1型在代谢综合征中的作用
- Author:
Xiantong ZOU
;
Linong JI
- Publication Type:Journal Article
- Keywords:
Metabolic syndrome (MS);
11β-hydroxysteroid dehydrogenase type 1(11β-HSD1);
Glu-cocorticoid
- From:Chinese Journal of Diabetes
2015;(4):378-380
- CountryChina
- Language:Chinese
-
Abstract:
[Summary] MS ,which is highly related tothe occurrence of cardiovascular disease and T2DM ,is characterized by glucose and fat metabolic dysregulation ,central obesity ,hypertension and hyperuricemia.11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) is regarded as a new therapeutic target for MS.11β‐HSD1 converts inactive glucocorticoid to active glucocorticoid. 11β‐HSD1 knockout improves obesity , hyperlipidemia andhyperglycemia. The inhibition of 11β‐HSD1 alleviates IR in human and rodents ,but the application of 11β‐HSD1 inhibitors is limited by the side effects.
