Preliminary Study on Targets of Traditional Chinese Medicine Compound in Chronic and Complex Disease Treatment Based on Collaterals

VernacularTitle:以络论治慢性复杂性疾病中药复方的作用靶点探索
Author: Lijian PANG ; Zhongxue ZHAO ; Chuang LIU ; Xiaodong LYU
Publication Type:Journal Article
Keywords: Treatment based on collaterals; chronic and complex disease; Chinese medicine compound; target
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2015;(2):319-323
CountryChina
Language:Chinese
Abstract: This article elaborated the theory of chronic and complex disease treatment based on collaterals. It put forward that complex virtual evil stasis was the common pathogenesis of chronic and complex disease treatment. Combined with articles published in recent 5 years, from the perspective of cytokines and genes, it summarized traditional Chinese medicine (TCM) compound targets in chronic and complex disease treatment. It put forward the transforming growth factor-β1 (TGF-β1), tumor necrosis factor-α(TNF-α), interleukin-6 (IL-6), vascular endothelial growth factors (VEGFs), matrix metalloproteinases/tissue inhibitor of metalloproteinase (MMPs/TIMPs) were its high-frequency targets. It provided a basis for future experiment design on chronic and complex disease treatment based on collaterals as well as new drug development.