Study on Relativity of AGEs, Inlfammatory Factor and Growth Factor in Ulcer-curation Process of Diabetic Feet Promoted by Yin-Huang-San
10.11842/wst.2015.02.010
- VernacularTitle:“蚓黄散”干预糖尿病足溃疡愈合过程中AGEs与促愈合因子相关性研究
- Author:
Youshan LI
;
Bohua YANG
- Publication Type:Journal Article
- Keywords:
Yin-Huang-San;
diabetic foot ulcer;
inflammatory factor;
growth factor;
AGEs
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2015;(2):350-355
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to discuss the external treatment of diabetic foot ulcer with traditional Chinese medicine (TCM) Yin-Huang-San (YHS) and to observe its promoting healing effect. Analysis was made on AGEs correlated with inflammatory factors and growth factors. A total of 60 patients with damp-heat-toxin pattern standard diabetic foot ulcer patients were randomly divided into the treatment group and control group. External application of YHS was given in the treatment group. And external application of metronidazole and glucose injection was given in the control group. The dressing was changed once a day. Blood was drawn 1 d before the treatment, and 7 d, 14 d, 21 d, 28 d after the medication. Improvements of patients’ clinical symptoms were observed. Dynamic monitoring was given on changes of hs-CRP, TNF-α, IL-1, VEGF, EGF, bFGF, PDGF and AGEs. The results showed that the total efficiency of the treatment group was 96.7%; and the total efficiency of the control group was 83.3%. Compared with the control group, external treatment with YHS can obviously improve clinical symptoms of diabetic foot ulcer (P<0.01), reduce AGEs and inflammatory factor, and increase the number of growth factors. AGEs had significant positive correlation with inflammatory factor; it had significant negative correlation with growth factors. It was concluded that YHS was effective in the treatment of diabetic foot ulcer patients with damp-heat-toxin pattern.
