Inlfuence of Extreme Environment Changes on IL-6, INF-γ, sIgA and IL-10 Rat Lung

VernacularTitle:极端环境变化对大鼠肺脏IL-6、INF-γ、sIgA和IL-10的影响
Author: Yuechao CAI ; Xiaoying XU ; Shuran MA ; Yan HENG
Publication Type:Journal Article
Keywords: Extreme environment; lung; immune; ELISA
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2015;(2):367-371
CountryChina
Language:Chinese
Abstract: This study was aimed to explore the influence of extreme environment changes on the lung immune function in rats. Artificial climate system was used to simulate six extreme weathers, which were the sudden temperature increase (ZS), sudden temperature drop (ZJ), continuous high temperature (CG), continuous low temperature (CD), high temperature and high humidity (GWGS), normal temperature and high humidity (CWGS). And then, the method of enzyme-linked immunosorbent assay (ELISA) was adopted to detect bronchoalveolar lavage fluid (BALF) and related immune substances in lung tissues. The results showed there was significant difference of ZJ on IL-10 (P<0.05). There were significant differences of CG, CD, GWGS, and CWGS on IL-6, INF-γ and sIgA (P<0.05). Contents of the GWGS group and CWGS group were higher than that of the CG group and CD group. There was very significant difference on IL-10 in the CD group (P<0.01). It was concluded that the extreme environment changes had different influence on body’s immune. And different intervention factors cause the body’s immune factors to response accordingly.