Research Progress on ERK Signaling Pathway in Brain Ischemic Tolerance Induced by Traditional Chinese Medicine

VernacularTitle:ERK信号通路在中药诱导脑缺血耐受中的研究进展
Author: Qingping ZHANG ; Deqing HUANG ; Tai LIU
Publication Type:Journal Article
Keywords: ERK signaling pathway; brain ischemic tolerance; traditional Chinese medicine inducing; review
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2015;(2):411-415
CountryChina
Language:Chinese
Abstract: Brain ischemic tolerance refers to endogenous brain protective mechanism during severe ischemic injury of the body. Ischemia preconditioning is an effective mean to induce brain ischemic tolerance. However, the invasive and ethical limitation made the application of ischemic preconditioning difficult in the clinical practice. Studies found that extracellular signal regulated kinase (ERK) signaling pathway played an important role in the formation of brain ischemic tolerance. Meanwhile, brain ischemic tolerance induced by traditional Chinese medicine (TCM) had its unique advantages. This article reviewed effects of ERK signaling pathway in the inducing of brain ischemic tolerance and TCM intervention in recent years.