Comparison of effects of cefepime, ceftazidime and cefathiamidine on bacterial infection in gynecology
10.3760/cma.j.issn.1008-6706.2015.06.024
- VernacularTitle:头孢吡肟、头孢他啶与头孢硫脒治疗妇科细菌感染的效果比较
- Author:
Haihong GAO
;
Mine LI
- Publication Type:Journal Article
- Keywords:
Bacterial infections;
Obstetrics and gynecology department,hospital;
Cefepime;
Ceftazidime;
Cefathiamidine
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(6):870-872
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of domestic cefepime ,ceftazidime and cefathiami-dine on bacterial infection in gynecology .Methods 460 patients were randomly divided into Group A (155 patients) for 2.0g.bid of cefepime,Group B (155 patients) for 2.0g.bid of ceftazidime and Group C (150 patient) for 2.0g. bid of cefathiamidine ( intramuscular injection:once every 12 hours ) , and the periods of treatment were all 7 to 10 days.Control observation and study was carried out following Guiding Principle of Clinical Application of Antibacterial Agents.Results The clinical efficacies in Groups A ,B and C were 94.84%,82.58% and 67.33%respectively(χ2 =11.63,37.96,all P<0.05);the bacterial clearance rates were 92.52%,81.38% and 64.71%respectively(χ2 =8.00,9.97,all P<0.05).The clinical efficacy of Group A >that of Group B>that of Group C;the adverse effectives were 9.68%,10.32% and 9.33% respectively (χ2 =0.09,P>0.05).Conclusion Cefepime may still be used as the first line drugs ,and drug resistance of various degrees has occurred to ceftazidime and cefathi -amidine,and especially cefathiamidine ,which should be used with caution .
