B cell line epitopes prediction of human cytomegalovirus glycoprotein B
10.7644/j.issn.1674-9960.2015.03.006
- VernacularTitle:人巨细胞病毒包膜糖蛋白B线性B细胞抗原表位的预测
- Author:
Jingjing YAN
;
Xiong ZHAO
;
Huiqiong YIN
;
Jingang ZHANG
- Publication Type:Journal Article
- Keywords:
human cytomegalovirus;
glycoprotein B;
B cell epitopes
- From:
Military Medical Sciences
2015;(3):184-188
- CountryChina
- Language:Chinese
-
Abstract:
Objective To predict the B cell line epitopes of human cytomegalovirus glycoprotein (gB)by analyzing its structure and physicochemical properties using bioinformatics approaches .Methods Based on the sequence of the HCMV gB,the probable B cell epitopes are predicted using two online prediction programs and DNAstar software .Meanwhile,the tertiary structure of gB was constructed by homologous modeling with the assistance of SWISS -MODEL server to rule out im-possible B cell epitopes .Results and Conclusion The B cell line epitopes of gB are predicted , which provides a theoreti-cal basis for further verification of gB immunodominant epitopes and screening the source plasma with high HCMV IgG titer .
