Study on the distribution of gene polymorphism of methylenetetrahydrofolate reductase and methionine syn-thase among the Han gestational age women in Sanhe City of Hebei Province
10.3760/cma.j.issn.1008-6706.2015.06.018
- VernacularTitle:河北省三河市汉族育龄女性亚甲基四氢叶酸还原酶和甲硫氨酸合成酶还原酶的遗传多态性分析
- Author:
Lijie LYU
;
Yanqiang LU
;
Shaojie MA
;
Jie ZHOU
;
Qi YANG
- Publication Type:Journal Article
- Keywords:
5,10-Methylenetetrahydrofolate reductase;
Methionine synthase reductase;
Genetic screening;
Female
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(6):853-856
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the genotype distribution of methylenetetrahydrofolate reductase ( MTH-FR)C677T,A1298C and methionine synthase reductase (MTRR) A66G involved in the folic acid biosynthetic path-way among Chinese Han gestational age women in Sanhe City .Methods 601 samples were recruited from Sanhe re-gion,genomic DNA was obtained from the oral mucosa cells .The detections of MTHFR and MTRR gene polymor-phisms conducted with Taqman -MGB technology .The distribution of gene polymorphisms of this study was analyzed and compared with partial regions of China ,which were reported.Results The frequency of MTHFR 677TT among Sanhe women(37.40%) was significantly different to Yanbian (28.30%),Zhenjiang(21.84%),Songzi(15.40%), Deyang(13.80%),Huizhou(10.90%),Qionghai(6.14%),Zibo(43.6%) (χ2 =12.60,87.44,151.95,233.02, 61.87,446.90,7.27,all P<0.05).The frequency of MTHFR 1298CC(2.30%) was significantly different to Zibo (1.44%),Zhenjiang(3.50%),Songzi(2.60%),Deyang(6.26%),Huizhou(7.20%),Qionghai(7.13%) (χ2 =5.84,6.49,14.32,32.54,22.94,53.12,all P<0.05).The frequency of MTRR 66GG (7.50%) was significantly different to Qionghai (9.25%),Songzi(6.40%)(χ2 =16.34,4.10,all P<0.05).Conclusion The MTHFR, MTRR polymorphism distribution of Han women in Sanhe City is region specific ,respective .
