Analysis and significance of results of hemoglobin electrophoresis in 7 652 cases
10.3969/j.issn.1673-4130.2015.06.014
- VernacularTitle:7652例血红蛋白电泳结果分析及意义
- Author:
Wangyun YI
;
Mingsheng YUAN
- Publication Type:Journal Article
- Keywords:
hemoglobin;
agarose gel electrophoresis;
hemoglobin diseases
- From:
International Journal of Laboratory Medicine
2015;(6):751-752
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the detection rates and types of hemoglobinopathy in Xiaolan district of Zhongshan city to provide the basis for prepotency .Methods 7 652 pregnant women with pregnancy detection in our hospital from June 2010 to De‐cember 2013 were selected and performed the electrophoresis by the Hydrasys automatic hemoglobin electrophoresis system .The hemoglobin components were scanned out and performed the statistical analysis .Results Among 7 652 samples ,1 057 cases of sus‐pected hemoglobinopathy were screened out with the detection rate of 10 .36% .Among them ,511 cases(6 .68% ) were Hb A2 <2 .0% (suspected α‐thalassemia) ,451 cases(5 .89% ) were Hb A > 3 .5% (suspected β‐thalassemia) ,the detection rate of Hb A2 >3 .5% was lower than that of Hb A2 < 2 .0% ,the difference had statistical significance(P< 0 .05) .11 cases (0 .14% ) were Hb C or E ,9 cases (0 .12% ) were Hb J or K ,8 cases (0 .10% ) were Hb H ,7 cases (0 .09% ) were Hb Bart′s ,1 case was Hb CS ,2 cases were Hb G and 1 case was Hb D ,which accounted for 0 .04% .Conclusion Hemoglobin electrophoresis can screen hemoglobinopa‐thy effectively .The hemoglobinopathy screening in this area should be conducted as soon as possible ,which has an important signif‐icance to prepotency .
