Cord blood Cytokines on the Development of Cerebral Palsy in Premature Infant.
- Author:
Ki Dae KIM
1
;
Byeong Hee SON
;
Chang Whan OH
;
Jung A LEE
;
Sung Won KIM
Author Information
1. Department of Pediatrics, St. Benedict Hospital, Busan, Korea. pedson40@yahoo.co.kr
- Publication Type:Original Article
- Keywords:
Cytokine;
Interlukin(IL-1beta, IL-6, TNF-alpha);
Cerebral palsy;
Premature
- MeSH:
Asphyxia;
Cerebral Palsy*;
Cytokines*;
Enzyme-Linked Immunosorbent Assay;
Fetal Blood*;
Humans;
Infant, Newborn;
Infant, Premature*;
Interleukin-6;
Medical Records;
Necrosis;
Paralysis;
Plasma;
Pneumonia;
Retrospective Studies;
Sepsis;
Tumor Necrosis Factor-alpha
- From:Korean Journal of Pediatrics
2004;47(12):1293-1299
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study was performed to determine the relation between cord blood plasma cytokines responses and development of cerebral palsies in premature infants. METHODS: Interleukin-1beta(IL-1beta), Interleukin-6(IL-6), Tumor necrosis factor-alpha(TNF-alpha) were measured using ELISA kits in premature infants(n=60) who were admitted to St. Benedict Hospital from September 2001 to June 2003. Retrospective study was done by review of medical records. RESULTS: Cord blood levels of IL-1beta, IL-6 and TNF-alpha in the cerebral palsy group were higher, especially IL-6 but were not significant, compared with the control group. Cord blood levels of IL-6 in the cerebral palsy without asphyxia, sepsis, PROM, RDS and pneumonia were significantly different, compared with the control group. CONCLUSION: Cord blood levels of IL-1beta, IL-6 and TNF-alpha in the cerebral palsy group were increased, but concentrations of IL-6 increased significantly. Cord blood levels of IL-6 may be a useful value to predict the development of cerebral palsy, because they are related to IL-6 rather than to TNF-alpha & IL-1beta in this study.
