Expression and significance of STK15 gene in parpillary thyroid carcinoma
10.3969/j.issn.1006-5725.2015.05.015
- VernacularTitle:丝氨酸／苏氨酸激酶15在甲状腺乳头状癌诊治中的意义
- Author:
Shuming SUN
;
Xiuxun YANG
;
Gengzhi CHEN
;
Xiaofeng LU
;
Haoyu LIN
;
Weiquan LIANG
;
Chunfa CHEN
- Publication Type:Journal Article
- Keywords:
Papillary Thyroid Carcinoma;
Serine/Threonine Kinase 15;
Diagnosis;
Treatment
- From:
The Journal of Practical Medicine
2015;(5):740-742
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of serine/threonine kinase 15 (STK15) gene and its significance for papillary thyroid carcinoma. Methods SP immunohistochemical method was used to detect the expression of STK15 gene in 71 cases of papillary thyroid carcinoma and 45 cases nodular goiter tissue. Results The positive expression rates of STK15 gene in 71 cases of papillary thyroid carcinoma were 100%, and the adjacent of papillary thyroid carcinoma expressions of STK15 gene 8.5%, nodular goiter tissue of STK15 gene expression rates 24.4%. The expression of STK15 gene was positively correlated with that of STK15 gene in papillary thyroid carcinoma (P < 0.01). Conclusion High expression of STK15 gene is confirmed in papillary thyroid carcinoma. The detection of STK15 gene can provide valuable evidence for diagnosis of papillary thyroid carcinoma and evaluation of the malignant potential of nodular goiter.
