Application of Dry Granulation Technology in Production of Lianhua Qingwen Capsules
10.3969/j.issn.1005-5304.2015.04.021
- VernacularTitle:干法制粒技术在连花清瘟胶囊生产中的应用
- Author:
Yufeng WANG
;
Chunrui LI
;
Song LI
;
Yue OUYANG
;
Wencheng FAN
;
Minyan LIU
- Publication Type:Journal Article
- Keywords:
Lianhua Qingwen Capsules;
dry granulation technology;
technology optimization;
comparative study
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2015;(4):74-76
- CountryChina
- Language:Chinese
-
Abstract:
Objective To solve the agglomeration problem in the former process, dry granulation technology was used to prepare the granules of Lianhua Qingwen Capsules. Methods Complexity and granule yield coefficient were set as inspection indexes. The optimum subsidiary material and its amount were optimized. The parameters of dry granulation technology were optimized by orthogonal test. Then, granule yield, angle of repose, and bulk density were compared with those of wet granulation technology. Results Starch was set as subsidiary material. The optimum technology is roll pressure of 12 MPa, rotation speed of 5 r/min, and feed speed of 10 r/min. The yield of granules prepared by dry granulation technology was significantly higher than that of wet granulation technology. Conclusion The dry granulation technology can effectively improve the agglomeration of the granulation process of Lianhua Qingwen Capsules, and was suitable for granulating process of Lianhua Qingwen Capsules.
