Mechanism of NLRC5 in diffuse large B-cell lymphoma
10.3760/cma.j.issn.1673-422X.2015.02.021
- VernacularTitle:NLRC5在弥漫性大B细胞淋巴瘤中的作用机制
- Author:
Yanlong QUAN
;
Yingqiong ZHOU
- Publication Type:Journal Article
- Keywords:
Lymphoma,large B-cell,diffuse;
NF-kappaB;
Genes,MHC class Ⅰ;
NLRC5
- From:
Journal of International Oncology
2015;42(2):157-160
- CountryChina
- Language:Chinese
-
Abstract:
Diffuse large B-cell lymphoma (DLBCL) is the most common malignant lymphoma in China,which mostly starting from the lymph nodes.The studies find that the expression of NLRC5,member of nucleotide-binding oligomerization domain-like receptor (NLR) family,is evident in the lymphoid cells,which is likely to be an important basis for lymphocyte tumorigenesis.NLRC5 can block the nuclear factor-κB (NF-κB),a core component of signal transduction pathway,and affect the development of tumor.While continuing activation of NF-κB is a necessary condition for DLBCL cell survival.Therefore,NLRC5 is likely to inhibit excessive inflammation,thereby inhibiting the function of DLBCL,which promises to be a new target for immunotherapy treatment of DLBCL.
