The role of HBXIP overexpression in the prognostic evaluation of breast cancer

VernacularTitle:乙肝病毒X蛋白结合蛋白过表达在乳腺癌诊断及预后评估中的意义
Author: Huamin ZHANG ; Nan LI ; Jie SUN ; Shuangping LIU
Publication Type:Journal Article
Keywords: Breast Cancer; HBXIP; Immunohistochemistry
From: The Journal of Practical Medicine 2015;(5):737-740
CountryChina
Language:Chinese
Abstract: Objective To investigate the role of HBXIP overexpression in the prognostic evaluation of breast cancer. Methods HBXIP expression was detected in the tissues of 60 breast cancer cases and 15 cases of ductal cancer in situ (DCIS) as well as in the adjacent non-tumorous tissues of 27 cases of breast cancer using EnVision immunohistochemical staining method. The correlations between the HBXIP overexpressions and the clinical pathological characters of the patients with breast cancer were also analyzed. Results The HBXIP proteins showed a major cytoplasmic staining pattern in breast cancer. The strongly positive rate of HBXIP was75.0%(45/60) in breast cancer, significantly higher than in DCIS (20.0%, 3/15) and adjacent non-tumorous tissues (14.8%, 4/27). High-level expression of HBXIP was correlated with late clinical stage, lymph node metastasis and HER-2 positive expression in breast cancer. Conclusions The expression level of HBXIP is closely related to the progression and prognosis of breast cancer. It might be a potential biomarker and therapeutic target of breast cancer.