Joint action of CXCL16 and TNF-α genes polymorphisms in patients with atherosclerotic cerebral infarction
10.3969/j.issn.1006-5725.2015.05.011
- VernacularTitle:趋化因子CXCL16和肿瘤坏死因子－α基因联合作用与动脉粥样硬化性脑梗死的相关性
- Author:
Dan LIU
;
Wei ZHANG
;
Hongying SUN
- Publication Type:Journal Article
- Keywords:
Cerebral infarction;
Chemokine CXCL16;
Tumor necrosis factor-α;
Polymorphisms;
Gene-gene interaction
- From:
The Journal of Practical Medicine
2015;(5):728-730
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the joint action of CXCL16 G1850A and TNF-α T1031C genes polymorphisms in patients with atherosclerotic cerebral infarction (ACI). Methods CXCL16 gene, G1850A and TNF-α gene T1031C mononucleotide polymorphism were tested with polymerase chain reaction followed by restriction fragment length polymorphism (PCR-RFLP) in 120 ACI patients and 75 healthy controls. Results The CXCL16 gene 1850 site AA genotype (35.8% vs 20.0%), A allele frequency (59.6% vs 44.0%), the TNF-αgene 1031 site CC genotype(2.5% vs 1.3%), C allele frequency(21.3% vs 11.3%)in ACI group were significantly higher than in the control group(P < 0.05). There was a positive correlation between the joint action of CXCL16 G1850A and TNF-α T1031C genes polymorphisms and ACI (χ2= 7.502,df = 2,P = 0.023). Conclusion The CXCL16 gene 1850, A allele and TNF-α gene 1031 C allele were risk factors for ACI. There is a positive correlation between the joint action of CXCL16 G1850A and TNF-α T1031C genes polymorphisms on ACI.
