Research progress of Sox-2 signaling regulation pathway and its mechanism in tumor development
- VernacularTitle:Sox-2调节信号通路及其在肿瘤发生发展机制中作用的研究进展
- Author:
Hanjun LI
;
Huijuan ZENG
;
Shaohua WANG
- Publication Type:Journal Article
- Keywords:
Sox-2;
Signal transduction pathways;
Cancer stem cell
- From:
Journal of Medical Postgraduates
2015;(3):313-317
- CountryChina
- Language:Chinese
-
Abstract:
Sox-2(SRY related HMG box-2)is an essential embryonic stem cell gene and a necessary transcription factor for maintaining the proliferation and self-renewal capability of embryonic stem cell .Sox-2 is involved in complex cell signal transduction pathway network and adjusting biological behavior of cells .Expression of Sox-2 is adjusted by different factors in transduction , transla-tion and post-translation levels .In recent years , increasing evidences indicate Sox-2 has an important role in tumor development , growth, proliferation, and metastasis, which is involved in various biological behavior of tumor cells in many types of tumors .This pa-per reviews the role of Sox-2 in adjusting tissue and tumor development and complex cell signal transduction pathway network of Sox -2 and clinical values of Sox-2 in tumor diagnosis and treatment until now .
