Clinical and pathological analysis of 11 cases of extraocular muscle paralysis was misdiagnosed as muscular disease myasthenia gravis
10.3969/j.issn.1671-8348.2015.09.022
- VernacularTitle:眼外肌瘫痪被误诊为重症肌无力的肌肉疾病11例临床及病理分析
- Author:
Xiaojuan MA
;
Fei XIAO
- Publication Type:Journal Article
- Keywords:
external ophthalmoplegia;
oculopharyngeal muscular dystrophy;
oculopharyngeal distal myopathy;
chronic pro-gressive external ophthalmoplegia
- From:
Chongqing Medicine
2015;(9):1221-1223
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the clinical and pathological characteristics of patients with myopathies that were misdiag-nosed as myasthenia gravis because of external ophthalmoplegia ,widen the thoughts for differential diagnosis of extraocular muscle paralysis .Methods The clinical and pathological features of 11 myopathy cases with ptosis and diplopia admitted to the neurology department of the First Affiliated Hospital of Chongqing Medical University between October 2010 and May 2014 were retrospec-tively reviewed and analyzed .Results Among the 11 patients ,6 male and 5 female ,aged 16-66 years old .All had paralysis of ex-traocular muscle manifestations ,including oculopharyngeal muscular dystrophy(OPMD) in 3 cases ,oculopharyngeal distal myopa-thy in 2 cases ,chronic progressive external ophthalmoplegia(CPEO) in 6 cases .Muscle biopsy showed the characteristic pathologi-cal changes .Statistical analysis showed that the age of onset in OPMD patients was older(P<0 .05) ,creatine kinase level in oculo-pharyngeal distal myopathy patients was higher ,but the difference was not significant (P>0 .05) .Conclusion Certain rare myopa-thy should be considered for patients with external ophthalmoplegia seemingly myasthenia gravis .Muscle biopsy can provide clue for differential diagnosis .
