Study on Multicomponent Sequential Metabolism in Rats with Chuanxiong Rhizoma
10.3969/j.issn.1005-5304.2015.04.022
- VernacularTitle:大鼠体内川芎多成分序贯代谢研究
- Author:
Beiran LV
;
Wenning YANG
;
Mingmin TANG
;
Li WEI
;
Xiaoyun MA
;
Zhiqiang LUO
;
Yang LIU
- Publication Type:Journal Article
- Keywords:
Chuanxiong Rhizoma;
multicomponent;
sequential metabolism;
closed-loop intestine method;
rats
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2015;(4):77-82
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the multicomponent in vivo dynamic process in Chuanxiong Rhizoma;To elaborate in vivo metabolic profiling. Methods HPLC was used to establish the fingerprint of aqueous extract of Chuanxiong Rhizoma, and multicomponent changes were detected at the same time. Closed-loop intestine method was used to study the multicomponent changes of oral administration of Chuanxiong Rhizoma after stomach-intestine-liver process. Results Totally 17 components were detected in the fingerprint of aqueous extract of Chuanxiong Rhizoma and they were basically stable in the digestive juice. For in vivo metabolism, 4 components were metabolized by intestinal flora;3 components were metabolized by liver;2 new components were the metabolites of intestinal flora;1 component was the metabolite of liver. Conclusion Multicomponent sequential metabolism and closed-loop intestine method were used to clarify that multicomponent metabolic profiling was feasible, and it could provide experimental basis for the metabolism of traditional Chinese medicine.
