Therapy effect of TA (docetaxel + pirarubicin) or AC(pirarubicin + cyclophosphamide) for neoadjuvant chemotherapy locally advanced breast cancer with triple negative
10.3760/cma.j.issn.1008-6315.2015.04.019
- VernacularTitle:TA 方案与 AC 方案在局部晚期三阴乳腺癌新辅助化疗的效果观察
- Author:
Haibin CUI
;
Xiyong BAI
;
Huaie GE
;
Wei ZHANG
;
Hui LIU
- Publication Type:Journal Article
- Keywords:
Triple negative breast cancer;
Neoadjuvant chemotherapy;
Docetaxel;
Pirarubicin;
Cyclophosphamide
- From:
Clinical Medicine of China
2015;(4):345-348
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of neoadjuvant chemotherapy regimens of TA or AC in the treatment of locally advanced triple negative breast cancer. Methods Data of 99 women with stageⅡ/ Ⅲ locally advanced triple negative breast cancer treated in the Centre Hospital of Cangzhou from Jan. 2006 to Dec. 2011 were retrospectively analyzed. These patients were divided into two groups based on the regimen of the neoadjuvant chemotherapy. Fifty-two cases were received TA regimen(Docetaxel 75 mg/ m2 and pirarubicin 50 mg/ m2 )and 47 cases were received AC( pirarubicin 50 mg/ m2 ,cyclophosphamide 600 mg/ m2 ). IV drip infusion was administered in both groups for 4 cycles before surgery,with 3 weeks for each cycle. The efficacy after treatment,the 2 year recurrence rate and overall survival rate after operation were compared between the two groups. Results The response rates in TA group were 88. 46% ,higher than that of AC group(57. 45% ),and the difference was statistically significant(χ2 = 12. 260,P < 0. 001). Furthermore,the rate of pathological grade 4 and 5 in TA group were 42. 3%(22 / 52)was superior to AC group(23. 4%(11 / 47);P = 0. 046). The 2-year recurrence rate and survival rate in TA group were 23. 08%(12 / 52)and 84. 62% ,as same as that in AC group ((27. 66%(13 / 47)and 80. 85% ;χ2 = 0. 400;P = 0. 53). Conclusion TA and AC are both effective in terms of females with stage Ⅱ/ Ⅲ locally advanced triple negative breast cancer treat with neoadjuvant chemotherapy. Moreover,TA is superior to AC. However,there is no statistical difference of 2-years recurrence rate and survival rate between two groups.
