EGFR-TKIS combined with radioactive 125I seed implantation for the treatment of advanced non-small-cell lung cancer：analysis of clinical effect
10.3969/j.issn.1008-794X.2015.03.011
- VernacularTitle:表皮生长因子受体酪氨酸激酶抑制剂联合放射性粒子植入治疗肺癌的疗效分析
- Author:
Xihui YING
;
Jiansong JI
;
Jianfei TU
;
Zhongwei ZHAO
;
Jingjing SONG
;
Dengke ZHANG
;
Minhua WU
- Publication Type:Journal Article
- Keywords:
non-small-cell lung cancer;
epidermal growth factor receptor tyrosine kinase inhibitor;
radioactive 125I seed
- From:
Journal of Interventional Radiology
2015;(3):226-230
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the short-term efficacy, safety and effectiveness of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) combined with radioactive 125I seed implantation in treating advanced non-small-cell lung cancer (NSCLC). Methods A total of 48 patients with inoperable and EGFR mutation-positive advance NSCLC were included in this study. The patients were divided into study group (n = 26) and control group (n = 22). Patients in the study group were treated with EGFR-TKIs combined with radioactive 125I seed implantation; while patients in the control group only received EGFR-TKIs treatment, which was kept on until the disease progressed. The clinical efficacy, and the incidence of side effect as well as the survival rate were determined, and the results were compared between the two groups. Results Local disease control rate of the study group and the control group was 92.3% and 68.2%respectively, the difference was statistically significant (P= 0.033), while the effective rate was 76.9% and 54.5%respectively, the difference was not significant (P=0.101). Progression-free survival (PFS) time of the study group and the control group was 14.1 months and 9.7 months respectively (P< 0.05). The one-year survival rate of the study group and the control group was 80.8%and 63.6%respectively (P<0.05), and the median survival time was 26.9 months and 17.1 months respectively (P < 0.05). The major complication caused by radioactive 125I seed implantation was pneumothorax. Conclusion For EGFR mutation-positive advance NSCLC, EGFR-TKIs together with radioactive 125I seed implantation is a safe and effective treatment.Its short-term efficacy is superior to pure EGFR-TKIs therapy. At present, this combination therapy is a new alternative for the treatment of EGFR mutation-positive advance NSCLC.
