Expression of GPR30,HRG1 and HER2 in breast cancer and their relationship with lymphatic metastasis
10.3969/j.issn.1671-8348.2015.07.005
- VernacularTitle:乳腺癌 GPR30、HRG1和 HER2表达与淋巴结转移关系的研究
- Author:
Shuqin RUAN
;
Gang LI
;
Shanwei WANG
;
Ping HAN
;
Zhixiang YANG
- Publication Type:Journal Article
- Keywords:
breast neoplasms;
lymphatic metastasis;
GPR30;
HRG1;
HER2
- From:
Chongqing Medicine
2015;(7):878-880
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of GPR30,HRG1 and HER2 including the activation status of HER2 (phosphorylated HER2)in invasive ductal breast cancers and their relationship with lymphatic metastasis.Methods The expres-sion of GPR30,HRG1,HER2 and pHER2 in 72 cases of specimens of invasive ductal breast cancers were examined by immunohis-tochemistry method.Results A moderate correlation between GPR30 and HRG1 was disclosed (r=0.597,P =0.000).There was strong correlation between pHER2 and GPR30 or HRG1(r=0.742,P =0.000;r=0.615,P =0.000).The expression of GPR30 and pHER2 in the lymphatic metastasis group was remarkably higher than in the group without lymphatic metastasis(P <0.05). Conclusion The interaction between GPR30 and HRG1 HER2 signal transduction pathways might be involved in the lymphatic metastasis in breast cancer.Blocking both of GPR30 and HRG1 signaling pathway could be a promising new strategy for breast cancer treatments.
