Research advancement of pro-apoptotic mechanisms of GRIM-19 and its related proteins
- VernacularTitle:GRIM-19及其相关蛋白促凋亡机制的研究进展
- Author:
Guohua SHEN
;
Huawei CAI
;
Zhen ZHAO
- Publication Type:Journal Article
- Keywords:
GRIM-19;
STAT3;
Apoptosis;
Tumorigenesis
- From:
Journal of Medical Postgraduates
2015;(3):303-307
- CountryChina
- Language:Chinese
-
Abstract:
Cancer development is a complex process that involves multiple genetic changes and multiple signaling pathways . Recent findings show that the GRIM-19 is a novel apoptosis regulation gene , and its gene mutations and loss of protein expression have been observed in many tumor types such as urinarysystem tumor , digestive system neoplasm , which are closely related to cancer devel-opment.Thus, GRIM-19 may be a potential target for gene therapy .Pro-apoptotic mechanisms of GRIM-19 and its related proteins such as STAT3,GW112,p16INK4aare overviewed in this article.
