Expression and significance of P16INK4,P57kip2 and Ki67 in hepatocellular carcinoma

VernacularTitle:细胞周期调控因子P16INK4、P57kip2和K i67在肝癌中的表达及意义
Author: Han GAO ; Tao ZHOU ; Chunjing ZHANG ; Shuyan LI ; Liping WANG ; Zhecheng LIU
Publication Type:Journal Article
Keywords: P16INK4; P57kip2; Ki67; hepatocellular carcinoma
From: Chongqing Medicine 2015;(9):1165-1167
CountryChina
Language:Chinese
Abstract: Objective Analysis the expression and significance of P16INK4 ,P57kip2 and Ki67 in hepatocellular carcinoma .Meth-ods 21 normal liver tissue ,48 hepatocellular carcinoma tissues and 48 corresponding adjacent tissue were collected for this study . Immunohistochemical analysis the expression levels of P16INK4 ,P57kip2 and Ki67 .Results P16INK4 and P57kip2 in hepatocellular carci-noma tissue were significantly lower ,the positive rates were 49 .3% and 34 .2% respectively ,Ki67 was significantly higher than the normal liver tissue and corresponding adjacent tissue ,the difference was statistically significant(P<0 .05) ,the results were consist-ent with the Western blot ;different differentiated group p57kip2 ,Ki67 expression and P16INK4 were significant differences(P<0 .05) . Conclusion Low expression of P16INK4 and P57kip2 ,the higher expression of Ki67 play an important role in the development of hepa-tocellular carcinoma .